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Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

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Related Experiment Video

Updated: Jul 2, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

Epidural steroid injections do not induce weight gain.

Silviu Brill1, Andrei Swartz, Gherta Brill

  • 1Department of Anesthesiology and Intensive Care, Pain Clinic, Chaim Sheba Medical Center, Tel-Hashomer, Israel. silviu.brill@sheba.health.gov.il

Current Drug Safety
|August 12, 2008
PubMed
Summary

Neuraxial steroid injections for low back pain did not cause significant weight gain in a 3-month study. This finding suggests that epidural steroid administration may not lead to unwanted weight changes in patients.

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Knee Arthrocentesis in Adults
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Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
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Published on: May 26, 2023

Knee Arthrocentesis in Adults
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Knee Arthrocentesis in Adults

Published on: February 25, 2022

Area of Science:

  • Pain Management
  • Endocrinology
  • Pharmacology

Background:

  • Neuraxial steroid administration is a long-standing treatment for radicular low back pain.
  • Systemic side effects of steroids include pituitary-adrenal axis suppression, weight gain, and osteoporosis.

Purpose of the Study:

  • To prospectively evaluate the impact of three consecutive epidural steroid injections on patient weight.
  • To investigate potential weight gain associated with methylprednisolone acetate treatment for chronic low back pain.

Main Methods:

  • A prospective study involving 108 patients with chronic low back pain.
  • Patients received three monthly epidural injections of 40 mg methylprednisolone acetate over 3 months.
  • Weight changes were monitored, with complete data available for 100 participants.

Main Results:

  • No statistically significant change in body weight was observed after the series of three epidural steroid injections.
  • Individual patient weight fluctuations were not systematically linked to the steroid treatment.

Conclusions:

  • Neuraxial steroid administration, specifically epidural methylprednisolone acetate, does not appear to induce significant weight gain in patients with chronic low back pain.
  • The study suggests that concerns regarding steroid-induced weight gain may be mitigated with this specific treatment regimen.