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Efficacy and safety study of fixed-dose combination of ceftriaxone-vancomycin injection in patients with various

Manu Chaudhary1, Sanjay Mohan Shrivastava, Rajesh Sehgal

  • 1Intellectual Scientific Division, R & D Centre, Venus Remedies Limited, Haryana, India.

Current Drug Safety
|August 12, 2008
PubMed

Insights

The fixed-dose combination of Ceftriaxone-Vancomycin effectively treats various bacterial infections. This antibiotic combination showed significant improvement in patients with infections, with no observed liver or kidney toxicity.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Medicine

Background:

  • Bacterial infections pose significant health risks across various tissues.
  • Effective antimicrobial therapy is crucial for managing diverse infections.
  • Evaluating fixed-dose combinations can optimize treatment regimens.

Purpose of the Study:

  • To assess the efficacy and safety of a fixed-dose combination of Ceftriaxone-Vancomycin.
  • To evaluate treatment outcomes in patients with multiple types of bacterial infections.
  • To determine the impact of the combination therapy on key clinical and biochemical markers.

Main Methods:

  • A randomized study involving 305 patients with bacterial infections.
  • Patients received intravenous Ceftriaxone-Vancomycin at 1.5 g B.D. or 3.0 g B.D. for 3-10 days.
  • Clinical cure rates and biochemical parameters (hemoglobin, leukocyte count, ESR, renal and liver function tests) were monitored.

Main Results:

  • 70% of patients achieved cure within seven days.
  • Significant reductions in total leukocyte count and erythrocyte sedimentation rate indicated infection resolution.
  • No adverse effects on hemoglobin, urea, creatinine, or liver enzymes were observed.

Conclusions:

  • The fixed-dose combination of Ceftriaxone-Vancomycin is an effective treatment for various bacterial infections.
  • The therapy demonstrated a favorable safety profile, with no significant toxicity to the liver or kidneys.
  • Patients tolerated the drug well, with minimal major adverse effects reported.

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