Monodisperse hyaluronan polymers: synthesis and potential applications
1Dept. of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, Univ. of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd, Oklahoma City, OK 73126, USA. paul-deangelis@ouhsc.edu
Abstract:
In many cases, the cellular response to hyaluronan (HA) depends on the molecular weight (MW) of the polymer chain. Most HA preparations from Nature or its derivatives possess wide size distributions called polydisperse. New chemoenzymatic synthesis technology allows the production of very narrow size distribution polymers called monodisperse. The use of stoichiometrically controlled and synchronized polymerization reactions allows an assortment of new HA reagents in the range of 10 kDa to 2,500 kDa for answering HA biology questions or potentially treating disease.
