Related Experiment Video
Updated: Jul 2, 2026
07:33
Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Intravenous immunoglobulin therapy in dermatologic disorders
Seray Külcü Cakmak1, Ulker Gül, Müzeyyen Gönül
1Turan Güneş Bulvari 71, Sokak 18/8 Yildiz, Cankaya, Ankara, Turkey. seraycakmak@yahoo.com
Inflammation & Allergy Drug Targets
|August 12, 2008
Summary
High-dose intravenous immunoglobulin (IVIG) shows promise for treating severe skin diseases, often alongside other therapies. Further research is needed to fully understand its mechanisms and confirm efficacy through rigorous trials.
Area of Science:
- Immunology
- Dermatology
Background:
- Intravenous immunoglobulin (IVIG) contains supra-physiologic levels of immunoglobulin G.
- IVIG is utilized for immunodeficiency, inflammatory, and infectious diseases.
- Its immunomodulatory mechanisms remain incompletely understood.
Purpose of the Study:
- To review the efficacy and safety of IVIG in treating dermatologic conditions.
- To highlight IVIG as a potential therapeutic option for severe skin diseases.
Main Methods:
- Review of existing evidence on IVIG in skin diseases.
- Focus on efficacy and safety data.
Main Results:
- Accumulating evidence suggests high-dose IVIG is effective for certain skin diseases.
- IVIG is often most effective when used with other immunomodulatory strategies.
- Lack of randomized, double-blind, placebo-controlled trials for many applications.
Conclusions:
- IVIG offers potential new treatment avenues for severe dermatologic conditions.
- Further rigorous clinical trials are necessary to establish definitive efficacy and safety profiles.
Related Concept Videos
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:24Nephrotic Syndrome III : Nursing Management
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
01:25Routes of Drug Administration: Parenteral
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...