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Updated: Jul 2, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

ADAM8 in allergy.

Osamu Matsuno¹, Toshihide Kumamoto, Yasunori Higuchi

¹Division of Respiraory Disease, Osaka Minami Medical Center, Kawachinagano-City, Osaka, Japan. matsuno@med.oita-u.ac.jp

Inflammation & Allergy Drug Targets

|August 12, 2008

Summary

ADAM8, a protein involved in immune responses, plays a key role in allergic inflammation and asthma. Targeting ADAM8 offers a promising therapeutic strategy for allergic respiratory diseases.

Area of Science:

Immunology
Molecular Biology
Respiratory Medicine

Background:

ADAM (a disintegrin and metalloprotease) proteins are crucial for various cellular functions, including cell adhesion and signaling.
ADAM8 (CD156a) is predominantly expressed in immune cells and functions as a sheddase for specific cell surface molecules.
ADAM8 is implicated in the pathogenesis of allergic inflammation and respiratory diseases like asthma.

Purpose of the Study:

To review the role of ADAM8 in allergic respiratory diseases.
To discuss novel immune intervention strategies targeting ADAM8 for therapeutic purposes.

Main Methods:

Review of existing literature on ADAM8 function and its role in allergic inflammation.
Analysis of ADAM8 expression patterns in disease progression and experimental models.

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Published on: June 4, 2017

Examination of ADAM8's substrate cleavage and its physiological impact.

Main Results:

ADAM8 expression is elevated in asthma and experimental allergic lung disease.
ADAM8 acts as a sheddase for CD23 and L-selectin, contributing to allergic inflammation.
Soluble ADAM8 levels are increased in patients with eosinophilic pneumonia.
ADAM8 exhibits a protective role against allergic pulmonary disease in murine models.

Conclusions:

ADAM8 is a significant mediator of allergic respiratory diseases.
Targeting ADAM8 presents a potential therapeutic avenue for allergic respiratory conditions.
Novel immune intervention strategies focusing on ADAM8 are under investigation.