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Updated: Jul 2, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
Published on: December 19, 2018
Molecular structural characteristics of estrogen receptor modulators as determinants of estrogen receptor selectivity
S Agatonovic-Kustrin1, J V Turner
1School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia.
Abstract:
This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
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