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Manual Segmentation of the Human Choroid Plexus Using Brain MRI
Published on: December 15, 2023
Choroid plexus tumors in 56 dogs (1985-2007)
D R Westworth1, P J Dickinson, W Vernau
1William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616-8747, USA.
Journal of Veterinary Internal Medicine
|August 12, 2008
Summary
Magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis can help differentiate between canine choroid plexus papillomas (CPPs) and choroid plexus carcinomas (CPCs). Higher CSF protein levels and MRI findings suggest malignancy in dogs with brain tumors.
Area of Science:
- Veterinary Neurology
- Comparative Oncology
- Diagnostic Imaging
Background:
- Choroid plexus tumors (CPTs) represent about 10% of primary brain tumors in dogs.
- The diagnostic value of MRI and CSF analysis for CPTs remains undetermined.
Purpose of the Study:
- To document MRI and CSF findings in dogs diagnosed with CPTs.
- To identify distinguishing features for differentiating tumor grades (papilloma vs. carcinoma).
Main Methods:
- Retrospective case series of 56 dogs with histologically confirmed CPTs.
- Blinded review of cranial MRI and cisternal CSF analyses.
- Statistical comparison of findings between choroid plexus papilloma (CPP) and choroid plexus carcinoma (CPC) groups.
Main Results:
- 36 dogs had CPCs, 20 had CPPs. Golden Retrievers were overrepresented.
- Median CSF protein was significantly higher in CPCs (108 mg/dL) than CPPs (34 mg/dL).
- CSF protein >80 mg/dL and evidence of metastasis on MRI were specific to CPCs.
Conclusions:
- MRI and CSF analysis aid in differentiating canine CPPs from CPCs.
- These diagnostic tools can offer crucial prognostic and pretreatment information for canine brain tumors.
