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Updated: Jul 2, 2026

Extracellular Vesicle Tissue Factor Activity Assay
Published on: December 29, 2023
Role of tissue factor disulfides and lipid rafts in signaling
Usha R Pendurthi1, L Vijaya Mohan Rao
1Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75708, USA. usha.pendurthi@uthct.edu
Abstract:
Tissue factor (TF) is a cellular receptor for coagulation factor VIIa (FVIIa), and the assembly of TF:FVIIa complexes on cell surfaces not only triggers the coagulation cascade but also transduces cell signaling via activation of protease-activated receptors. This brief review summarizes recent controversial data on the importance of protein disulfide isomerase-mediated disulfide bond switching in extracellular domain of TF in regulating its coagulant and cell-signaling activities. The review also discusses the importance of TF localization in lipid rafts and caveolae in maintaining its coagulant and signaling functions.
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