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Pediococcus pentosaceus NB-17 for probiotic use.

Benjamas Jonganurakkun1, Qi Wang, Shan Hua Xu

  • 1Nisseibio Co., Ltd, 1-13 Megumino Kita 3-chome, Eniwa, Hokkaido 061-1374, Japan. ben@nisseibio.co.jp

Journal of Bioscience and Bioengineering
|August 12, 2008
PubMed
Summary
This summary is machine-generated.

Pediococcus pentosaceus NB-17, isolated from pickles, stimulates immune responses and inhibits allergies. This probiotic strain survives simulated gastric conditions and remains viable in the gut, suggesting its potential as a functional food ingredient.

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Area of Science:

  • Microbiology
  • Immunology
  • Food Science

Background:

  • Pediococcus pentosaceus NB-17 is a plant-derived lactic acid bacterium isolated from traditional Japanese vegetable pickles.
  • Probiotics are known to modulate immune responses and offer health benefits.

Purpose of the Study:

  • To investigate the immunomodulatory and anti-allergic effects of Pediococcus pentosaceus NB-17 in vitro.
  • To assess the acid tolerance and gastrointestinal survival of Pediococcus pentosaceus NB-17.

Main Methods:

  • Heat-killed Pediococcus pentosaceus NB-17 was co-cultivated with mouse spleen cells.
  • Cytokine production (IFN-gamma, IL-12 p70, IL-4) was measured.
  • Acid tolerance was tested under simulated gastric conditions (pH 3.0, 2.5).
  • Oral administration to rats and fecal analysis using RAPD confirmed strain survival.

Main Results:

  • Pediococcus pentosaceus NB-17 significantly induced interferon-gamma and interleukin-12 p70 secretion.
  • It suppressed interleukin-4 production in ovalbumin-sensitized mouse spleen cells, indicating anti-allergic effects.
  • The strain demonstrated resistance to simulated gastric acidity and remained viable in rat feces after oral administration.

Conclusions:

  • Pediococcus pentosaceus NB-17 exhibits potent immune-stimulating and anti-allergic properties.
  • Its demonstrated acid tolerance and gastrointestinal survival support its potential as a functional food ingredient.
  • Further research into Pediococcus pentosaceus NB-17 could lead to novel probiotic applications.