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Related Experiment Video

Updated: Jul 2, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

Complementary and alternative medicine for perinatal depression.

Marlene P Freeman1

  • 1Women's Mental Health Center, University of Texas Southwestern Medical Center, 6363 Forest Park, Suite 800, Dallas, TX 75235-9086, United States. marlene.freeman@utsouthwestern.edu

Journal of Affective Disorders
|August 12, 2008
PubMed
Summary

Complementary and Alternative Medicine (CAM) treatments for perinatal depression are understudied, with omega-3 fatty acids showing mixed results. More research is needed for safe and effective options for women with perinatal major depressive disorder (MDD).

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Area of Science:

  • Perinatal psychiatry
  • Integrative medicine
  • Evidence-based practice

Background:

  • Perinatal Major Depressive Disorder (MDD) presents significant treatment challenges.
  • Complementary and Alternative Medicine (CAM) is frequently used by women, particularly for MDD.
  • There is a need for well-studied CAM interventions for perinatal depression.

Purpose of the Study:

  • To review the evidence base for commonly used CAM treatments for perinatal depression.
  • To identify potential CAM therapies that could be safely integrated into perinatal mental healthcare.
  • To highlight areas requiring further investigation in CAM for perinatal MDD.

Main Methods:

  • A comprehensive literature search of PubMed/Medline was performed.
  • The search focused on CAM treatments, major depressive disorder (MDD), and perinatal depression.
  • Evidence for specific CAM interventions was systematically assessed.

Main Results:

  • Omega-3 fatty acids have the most extensive research for perinatal depression, but clinical trial results are conflicting.
  • Supplements like omega-3 fatty acids, exercise, and folate offer general health benefits but lack sufficient evidence for monotherapy.
  • S-adenosyl-methionine (SAMe) and bright light therapy show promise for MDD, while St. John's Wort requires further safety evaluation in pregnancy.

Conclusions:

  • Further research is essential to establish the efficacy and safety of CAM for perinatal depression.
  • Developing safe, effective, and accessible treatment options is crucial for managing perinatal depression.
  • The clinical application of CAM in perinatal mental health requires more robust scientific validation.