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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

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Published on: October 20, 2016

Quantitative analysis of echocardiographic cine-loops using a 2D-strain algorithm in correlation with thallium-201

Aaron Miller¹, Pierre Chouraqui, Gil Zwirn

¹The Abramson Center of Medical Physics, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel. aaronisme@yahoo.com

Ultrasound in Medicine & Biology

|August 12, 2008

Summary

This study found a moderate correlation between regional left ventricular (LV) contractility measured by 2D-strain echocardiography and LV perfusion assessed by SPECT imaging in patients with suspected myocardial ischemia.

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Last Updated: Jul 2, 2026

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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Area of Science:

Cardiology
Medical Imaging
Echocardiography

Background:

Assessing regional left ventricular (LV) function and perfusion is crucial for diagnosing and managing myocardial ischemia.
Two-dimensional (2D)-strain echocardiography offers a quantitative method to evaluate regional LV contractility.
Thallium-201 single photon emission computed tomography (SPECT) is a standard technique for assessing regional LV myocardial perfusion.

Purpose of the Study:

To investigate the correlation between regional LV contractility derived from 2D-strain echocardiography and regional LV perfusion determined by SPECT imaging.
To evaluate the feasibility of correlating these two imaging modalities in patients with suspected myocardial ischemia.

Main Methods:

Forty-five patients with suspected myocardial ischemia underwent same-day 2D-strain echocardiography and SPECT imaging.
2D-strain echocardiography provided peak systolic longitudinal strain measurements from three apical views.
SPECT imaging provided regional myocardial perfusion data, which were compared with strain data after image registration.

Main Results:

The overall mean correlation coefficient between SPECT perfusion and 2D-strain measurements was 0.56.
Correlation coefficients varied by view, with the apical four-chamber view showing the highest correlation (0.64).
A nonlinear relationship was observed between regional perfusion and strain values.

Conclusions:

Regional LV contractility assessed by 2D-strain echocardiography shows a moderate correlation with regional LV perfusion determined by SPECT.
These findings suggest that 2D-strain echocardiography can provide complementary information to SPECT for evaluating myocardial viability and ischemia.
Further research may explore the combined use of these techniques for improved patient management.