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Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

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Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Circulating endothelial progenitor cells decrease in patients after endarterectomy.

Andreas Stein1, Hans Peter Montens, Birgit Steppich

  • 1Deutsches Herzzentrum der TU München, München, Germany.

Journal of Vascular Surgery
|August 12, 2008
PubMed
Summary
This summary is machine-generated.

Endarterectomy reduces circulating endothelial progenitor cells (EPCs), potentially by recruiting them to injured vessels. Plaque inflammation negatively correlates with preoperative EPC levels, suggesting a role in vascular repair.

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Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Area of Science:

  • Vascular Biology
  • Regenerative Medicine
  • Immunology

Background:

  • Endothelial progenitor cells (EPCs) are crucial for vascular regeneration.
  • Surgical trauma and burns trigger inflammatory and proangiogenic responses.
  • Investigating EPCs and inflammation after endarterectomy provides insights into vascular injury responses.

Purpose of the Study:

  • To examine the impact of endarterectomy on circulating EPC numbers.
  • To analyze systemic inflammatory changes post-endarterectomy.
  • To correlate EPC levels with inflammatory markers and plaque characteristics.

Main Methods:

  • Flow cytometry was used to quantify circulating progenitor cells (CD133+CD34+, VEGFR-2+CD34+) and neutrophil activation (CD11b).
  • EPCs were functionally characterized via DiI-LDL uptake and lectin binding assays.
  • Plasma and tissue cytokine levels (IL-6, IL-8, TNF-alpha, etc.) were measured, alongside local IL-6 in plaque samples.

Main Results:

  • Endarterectomy led to a significant decrease in circulating EPCs (CD133+CD34+, VEGFR-2+CD34+).
  • This decline correlated with altered cytokine profiles (decreased IL-1β, IL-12; increased IL-6, G-CSF) and increased neutrophil CD11b expression.
  • Minor surgery showed increased EPCs and different cytokine changes (IL-6, IL-8, IL-10).

Conclusions:

  • Endarterectomy alters circulating cytokines and reduces EPCs, likely due to their recruitment to the site of vascular injury.
  • A negative association between preoperative circulating EPCs and local plaque IL-6 suggests inflammation influences EPC availability.