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NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose

Published on: December 30, 2025

Iron oxide nanoparticles-chitosan composite based glucose biosensor.

Ajeet Kaushik¹, Raju Khan, Pratima R Solanki

¹Biomolecular Electronics & Conducting Polymer Research Group, National Physical Laboratory, K.S. Krishnan Marg, New Delhi 110012, India.

Biosensors & Bioelectronics

|August 12, 2008

Summary

This summary is machine-generated.

This study developed a novel glucose biosensor using iron oxide nanoparticles and chitosan. The resulting nanocomposite bioelectrode demonstrates rapid response and high sensitivity for glucose detection.

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Area of Science:

Biomaterials Science
Nanotechnology
Electrochemistry

Background:

Development of sensitive and selective glucose biosensors is crucial for diabetes management.
Nanomaterials offer unique properties for enhancing biosensor performance.
Chitosan is a biocompatible polymer widely used in biosensor fabrication.

Purpose of the Study:

To fabricate a novel glucose biosensor based on iron oxide-chitosan nanocomposite.
To immobilize glucose oxidase onto the nanocomposite film for enhanced detection.
To characterize the electrochemical properties and performance of the developed bioelectrode.

Main Methods:

Fabrication of iron oxide (Fe(3)O(4)) nanoparticles via co-precipitation.
Dispersion of nanoparticles in chitosan solution to form a nanocomposite film on ITO glass.
Immobilization of glucose oxidase (GOx) onto the nanocomposite film via physical adsorption.
Characterization using XRD, TEM, UV-Vis, FTIR, and SEM.
Electrochemical performance evaluation of the GOx/CH-Fe(3)O(4)/ITO bioelectrode.

Main Results:

Fe(3)O(4) nanoparticles of approximately 22 nm size were synthesized.
The nanocomposite film and bioelectrode were successfully fabricated and characterized.
The developed bioelectrode exhibited a fast response time of 5s.
Linearity ranged from 10-400 mg/dL with a sensitivity of 9.3 µA/(mg/dLcm(2)).
A high affinity for glucose was indicated by a Michaelis-Menten constant (K(m)) of 0.141 mM.
A shelf life of approximately 8 weeks was observed under refrigerated conditions.

Conclusions:

The fabricated GOx/CH-Fe(3)O(4)/ITO nanocomposite bioelectrode is a promising platform for sensitive and rapid glucose detection.
The combination of iron oxide nanoparticles and chitosan enhances the performance of the glucose biosensor.
This approach offers a viable strategy for developing advanced electrochemical biosensing devices.