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Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
X-Inactivation01:58

X-Inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
X-inactivation01:58

X-inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Torque01:10

Torque

Torque is an important quantity for describing the dynamics of a rotating rigid body. We see the application of torque in many ways in the world, such as when pressing the accelerator in a car, which causes the engine to apply additional torque on the drivetrain. Here, we define torque and provide a framework to create an equation to calculate torque for a rigid body with fixed-axis rotation.
Torque can be considered as the rotational counterpart to force. Since forces change the translational...
Crossing Over01:30

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...
The X̄ Chart00:58

The X̄ Chart

The  x̄ chart is a statistical tool for monitoring the means in a process.
The x̄ chart, often known as the individual control chart, is a crucial tool in statistical process control. It is designed to monitor process behavior and performance over time and is widely used in various industries to ensure that processes are operating at their optimum capacity and within specified limits.
A x̄ chart is constructed by plotting individual measurements of a quality characteristic in the order in which...

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Related Experiment Video

Updated: May 11, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
12:47

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Published on: May 14, 2012

Otx2's incredible journey.

Alexandra Rebsam1, Carol A Mason

  • 1Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 W. 168(th) Street, 14-509 P&S Building, New York, NY 10032, USA. adr2111@columbia.edu

Cell
|August 12, 2008
PubMed
Summary

Visual experience drives Otx2 transfer to cortical interneurons, promoting inhibitory circuit maturation. This cell-to-cell transfer opens the critical period for visual cortex plasticity in mice.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Neuroscience

Background:

  • Postnatal neuronal plasticity is crucial for sensory system development.
  • The mechanisms regulating the opening and closing of critical periods remain incompletely understood.

Discussion:

  • Sugiyama et al. reveal a novel mechanism involving cell-to-cell transfer of the homeoprotein Otx2.
  • This transfer specifically targets cortical interneurons following visual experience.
  • Otx2 acts as a key regulator, promoting the maturation of inhibitory neural circuits.

Key Insights:

  • Visual experience initiates the transfer of Otx2 between cells.
  • Otx2 facilitates the maturation of inhibitory circuitry in the visual cortex.
  • This process is essential for opening the critical period of plasticity.

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Functional Cloning Using a Xenopus Oocyte Expression System

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Related Experiment Videos

Last Updated: May 11, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
12:47

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Published on: May 14, 2012

Functional Cloning Using a Xenopus Oocyte Expression System
09:40

Functional Cloning Using a Xenopus Oocyte Expression System

Published on: January 30, 2016

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Outlook:

  • Further research could explore Otx2's role in other sensory systems or developmental stages.
  • Understanding this mechanism may offer insights into developmental disorders affecting neural circuitry.