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Updated: Jul 2, 2026
Solid Plate-based Dietary Restriction in Caenorhabditis elegans
Published on: May 28, 2011
Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
Nadine Saul1, Kerstin Pietsch, Ralph Menzel
1Humboldt-Universität zu Berlin, Department of Biology, Arboretum, Spaethstr. 80/81, 12437 Berlin, Germany. nadines1976@aol.com
Abstract:
The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
