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Related Experiment Video

Updated: Jul 2, 2026

Rearing the Fruit Fly Drosophila melanogaster Under Axenic and Gnotobiotic Conditions

Rearing the Fruit Fly Drosophila melanogaster Under Axenic and Gnotobiotic Conditions

Published on: July 30, 2016

How do flies tolerate microorganisms in the gut?

Won-Jae Lee¹

¹Division of Molecular and Pharmaceutical Science and Department of Life Science, Ewha Woman's University, and National Creative Research Initiative Center for Symbiosystem, Seoul 120-750, South Korea. lwj@ewha.ac.kr

Cell Host & Microbe

|August 12, 2008

Summary

The PIMS gene product promotes immune tolerance in the gut by limiting peptidoglycan receptor availability. This discovery offers new insights into maintaining balanced host-microbe interactions within the gut epithelium.

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Last Updated: Jul 2, 2026

Rearing the Fruit Fly Drosophila melanogaster Under Axenic and Gnotobiotic Conditions

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Published on: July 30, 2016

Detection of Foodborne Bacterial Pathogens from Individual Filth Flies

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Systemic Bacterial Infection and Immune Defense Phenotypes in Drosophila Melanogaster

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Area of Science:

Immunology
Microbiology
Cell Biology

Background:

Gut epithelia constantly interact with microbial components like peptidoglycan.
A robust immune response is typically avoided despite this continuous exposure.

Discussion:

Lhocine et al. identify the PIMS gene product as a key regulator of gut immune tolerance.
PIMS reduces the availability of the peptidoglycan receptor on the plasma membrane.

Key Insights:

The PIMS gene product actively suppresses immune responses to gut microbes.
This mechanism involves modulating the accessibility of peptidoglycan receptors.

Outlook:

Understanding PIMS offers novel therapeutic targets for inflammatory gut conditions.
Further research can elucidate the precise signaling pathways regulated by PIMS.