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Juan Giles1, Antonio Requena, Juan Antonio García-Velasco

  • 1IVI Madrid, Calle Santiago de Compostela 88, Madrid, Spain. jgiles@ivi.es

Fertility and Sterility
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The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...