Related Experiment Video
Updated: Jul 2, 2026
Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps
Published on: August 2, 2024
Progression of conservatively treated endometrial complex atypical hyperplasia in a young woman: a case report
Giacomo Corrado1, Ermelinda Baiocco, Mariantonia Carosi
1Division of Gynecologic Oncology, National Cancer Institute Regina Elena, Rome, Italy. giacomo.corrado@alice.it
Objective:
To describe a case of progression of endometrial complex atypical hyperplasia (CAH) to extrauterine endometrioid adenocarcinoma in a patient who had requested fertility-sparing management.
Design:
Case report.
Setting:
Division of Gynecologic Oncology, National Cancer Institute "Regina Elena," Rome, Italy.
Patient(S):
A nulliparous 36-year-old woman with endometrial CAH who decided on a conservative approach.
Intervention(S):
Conservative hysteroscopic resection of the lesion, the surrounding endometrium, and underlying myometrium plus hormone therapy regimen of megestrol acetate (160 mg) daily for 6 months.
Main Outcome Measure(S):
Failure of the conservative therapy and progression of disease.
Result(S):
Eighteen months after fertility-sparing management, a laparoscopic operation revealed grade 2 endometrium adenocarcinoma with superficial myometrial invasion and a microscopic metastasis of the left ovary and Douglas peritoneum. The patient underwent adjuvant chemotherapy followed by external beam radiation of the pelvis and brachytherapy. Twenty-five months after, she was free of disease.
Conclusion(S):
Conservative therapy is feasible in carefully selected young women with endometrial CAH. However, close follow-up is required because of possible progression to endometrial cancer.
Related Concept Videos
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia