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Published on: August 11, 2023
Follicle-stimulating hormone levels and medication compliance during in vitro fertilization
Dorette J Noorhasan1, David H McCulloh, Michael Cho
1Department of Obstetrics, Division of Reproductive Endocrinology and Infertility, New Jersey Medical School-UMDNJ, Newark, New Jersey 07101, USA.
Objective:
To report the use of serum FSH levels during gonadotropin therapy for IVF to ensure medication compliance.
Design:
Case report.
Setting:
University-based reproductive endocrinology clinic.
Patient(S):
Two women with normal ovarian reserve undergoing IVF cycles with unexpected clinical responses.
Intervention(S):
FSH laboratory values.
Main Outcome Measure(S):
Ovarian follicular development.
Result(S):
Adequate follicular response leading to oocyte retrieval.
Conclusion(S):
Determination of serum FSH levels may help detect noncompliance with recommended gonadotropin regimens during IVF.
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At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
