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Assessment of biochemical recurrence rate in patients with pathologically confirmed insignificant prostate cancer
Umberto Capitanio1, Sasha Ahyai, Markus Graefen
1Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada.
Objectives:
To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa).
Methods:
A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole-mounted, step-sectioned, and subjected to computer-based three-dimensional reconstruction. We identified patients who fulfilled the Epstein criteria for definition of PIPCa (tumor volume
Results:
Pathologically confirmed insignificant prostate cancer was found in 69 patients (5%). At 1, 2, 5, and 10 years, the BCR-free rate for PIPCa patients was 100% vs, respectively, 97%, 91%, 74%, and 38% for other patients (log-rank P <.0001).
Conclusions:
In patients with PIPCa, radical prostatectomy results in perfect biochemical recurrence rates, which confirms the validity of the PIPCa definition.
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