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An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity
P Daisy1, R Jasmine, S Ignacimuthu
1Department of Biotechnology, Holy Cross College, Tiruchirappalli 620002, India.
Abstract:
Acetone extract of Elephantopus scaber, an ethnomedicnal plant, reduced the blood glucose levels in streptozotocin-induced diabetic rats significantly. Acute toxicity studies revealed the non-toxic nature of the crude extract. Fractionation of the acetone extract yielded a new steroid, 28Nor-22(R)Witha 2,6,23-trienolide. Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats. This compound can be a useful candidate to treat diabetes.
