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Cellular blue nevus with nevus cells in a sentinel lymph node.
Noriyuki Misago1, Kohtarou Nagase, Shuji Toda
1Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. misago@post.saga-med.ac.jp
European Journal of Dermatology : EJD
|August 12, 2008
Summary
Cellular blue nevi can involve lymph nodes, but this study shows benign cellular blue nevi in a sentinel lymph node. Immunohistochemical analysis supports a benign diagnosis for these nodal nevus cells.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Cellular blue nevi are typically benign melanocytic proliferations.
- Regional lymph node involvement by cellular blue nevi is uncommon.
- The distinction between benign involvement and malignancy is critical.
Observation:
- A case of cellular blue nevus with metastasis to a sentinel lymph node was analyzed.
- Nevus cells were identified within the lymph node capsule, fibrous trabeculae, and parenchyma.
- Immunohistochemical staining (c-kit, Ki-67, PCNA) was performed on nodal nevus cells.
Findings:
- Nodal nevus cells were predominantly located within the lymph node capsule and trabeculae.
- Isolated nevus cells were found in the lymph node parenchyma.
- Immunohistochemical profiles (c-kit+, Ki-67-, PCNA-) were consistent with benign melanocytes.
Implications:
- The findings suggest that lymph node involvement by cellular blue nevus can be benign.
- Capsular and trabecular location, along with benign cytology and specific immunohistochemical markers, indicate a benign process.
- This aids in accurate diagnosis and management of cellular blue nevi with nodal involvement.
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