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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...

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Related Experiment Video

Updated: Jul 2, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

Severe constipation associated with extended-release bupropion therapy.

Jody L Lounsbery¹, Mitchell A Medow, Christopher G Green

¹Department of Pharmaceutical Care and Health Systems, University of Minnesota College of Pharmacy, Minneapolis, MN 55455, USA. loun0015@umn.edu

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|August 12, 2008

Summary

This summary is machine-generated.

Bupropion, an antidepressant, can cause severe constipation, leading to complications like hemorrhoids. Discontinuing bupropion resolved the constipation in one reported case.

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Last Updated: Jul 2, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

Area of Science:

Pharmacology
Gastroenterology
Psychiatry

Background:

Bupropion is a widely prescribed antidepressant.
Gastrointestinal side effects, including constipation, are known adverse effects of bupropion.
Severe constipation can lead to significant complications such as hemorrhoids and anal fissures.

Observation:

A case study details a 38-year-old male patient experiencing severe constipation and hemorrhoids after initiating extended-release bupropion for depression.
Despite conservative management and symptomatic treatment for hemorrhoids, the constipation persisted, necessitating surgical intervention.

Findings:

The patient's severe constipation resolved after voluntarily discontinuing bupropion.
This suggests a probable causal link between extended-release bupropion and the development of severe constipation in this individual.

Implications:

Clinicians should be vigilant for gastrointestinal side effects, particularly constipation, in patients prescribed bupropion.
Further research may be warranted to explore the incidence and mechanisms of bupropion-induced constipation and its management.