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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis

Stefanie B Bumpus1, Nathan A Magarvey, Neil L Kelleher

  • 1Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

Journal of the American Chemical Society
|August 13, 2008
PubMed
Summary

Researchers identified PksE, a trans-acting enoyl reductase, essential for synthesizing the saturated bond in Bacillus subtilis dihydrobacillaene. This finding reveals a novel enoyl reduction pathway in polyketide biosynthesis, potentially linking it to polyunsaturated fatty acid machinery.

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