Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RAAVioli: A comprehensive approach to characterizing AAV vector integrations and rearrangements.

Molecular therapy. Advances·2026
Same author

Longitudinal and combined assessment of 24(S)-hydroxycholesterol and Neurofilament light chain in the early stages of Huntington's disease.

Neurobiology of disease·2026
Same author

Cross-Generational Validation of a Feedforward Neural Network for Milk Yield Prediction in Dairy Cattle.

Animals : an open access journal from MDPI·2026
Same author

Understanding the impact of sleep on cardiovascular risk estimation: comparison of LS7 and LE8 performances in a European population.

American journal of preventive cardiology·2026
Same author

BioGAN: Enhancing Transcriptomic Data Generation with Biological Knowledge.

Bioengineering (Basel, Switzerland)·2025
Same author

An epidemiological knowledge graph extracted from the World Health Organization's Disease Outbreak News.

Scientific data·2025

Related Experiment Video

Updated: Jul 2, 2026

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
05:22

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress

Published on: July 29, 2022

Exploration and statistical analysis of human gene expression annotations.

Mario Ceresa1, Marco Masseroli

  • 1Diprtimento di Elettronica e Infromazione,Politecnico di Milano, Milan, Italy.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|August 13, 2008
PubMed
Summary

This study enhances GFINDer, a web server for gene function analysis, by integrating gene expression data. This allows for more accurate annotation and statistical analysis of human gene sequences, improving understanding of gene functions.

More Related Videos

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Related Experiment Videos

Last Updated: Jul 2, 2026

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
05:22

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress

Published on: July 29, 2022

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • Gene expression data is crucial for understanding gene function.
  • Existing genomic annotation databases are often sparse.
  • GFINDer was previously developed for analyzing gene function and phenotype annotations.

Purpose of the Study:

  • To integrate gene expression information into the GFINDer web server.
  • To enable statistical analysis of gene expression features for human nucleotide sequences.
  • To improve the annotation of gene lists using expression data.

Main Methods:

  • Developed new modules for GFINDer.
  • Integrated eVOC ontologies for gene expression data.
  • Implemented annotation and statistical analysis of user-classified human nucleotide sequences.

Main Results:

  • GFINDer now supports the analysis of gene expression features.
  • User-classified human gene sequences can be annotated with controlled expression information.
  • Statistical analysis of expression-annotated gene lists is now possible.

Conclusions:

  • The enhanced GFINDer provides a valuable tool for exploring gene functions through expression analysis.
  • This integration improves the utility of genomic annotations.
  • Facilitates a deeper understanding of gene roles based on expression patterns.