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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
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Silica-based multimodal/multifunctional nanoparticles for bioimaging and biosensing applications.

Padmavathy Tallury1, Keith Payton, Swadeshmukul Santra

  • 1Nanoscience Technology Center, University of Central Florida, Orlando, FL 32826, USA.

Nanomedicine (London, England)
|August 13, 2008
PubMed
Summary

Nanoparticle technology offers noninvasive bioimaging and biosensing for early disease detection. This review highlights silica nanoparticles engineered for advanced biosensing and multimodal bioimaging applications.

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Last Updated: Jul 2, 2026

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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Materials Science and Nanotechnology

Background:

  • Nanoparticle (NP) technology is pivotal in bioimaging and biosensing, offering sensitive, noninvasive data acquisition.
  • Potential applications include early cancer diagnosis, stem cell tracking, drug delivery, and pathogen/gene delivery.
  • Robust NP engineering, synthesis, surface modification, and bioconjugation are crucial for successful applications.

Purpose of the Study:

  • To review silica nanoparticles developed for biosensing applications.
  • To discuss silica-based multimodal/multifunctional nanoparticles for bioimaging.

Main Methods:

  • Focus on NP design, synthesis, surface modification, and bioconjugation strategies.
  • Review of literature on silica nanoparticle development for biosensing.
  • Analysis of silica-based multimodal/multifunctional NPs for bioimaging.

Main Results:

  • Silica nanoparticles demonstrate significant potential in sensitive biosensing.
  • Silica-based multimodal/multifunctional NPs enable versatile bioimaging capabilities.
  • Key NP characteristics for optimal performance include sensitivity, stability, imageability, biocompatibility, and targetability.

Conclusions:

  • Engineered silica nanoparticles are critical for advancing biosensing and bioimaging technologies.
  • Multimodal and multifunctional silica NPs offer enhanced capabilities for diverse biomedical applications.
  • Further development in NP synthesis and engineering will drive wider clinical adoption.