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NF-kappaB in carcinoma therapy and prevention
Matthew Brown1, Jonah Cohen, Pattatheyil Arun
1National Institute on Deafness and Other Communication Disorders, Head and Neck Surgery Branch, Bethesda, MD 20892, USA.
Background:
NF-kappaB includes a family of signal-activated transcription factors that normally regulate responses to injury and infection but which are aberrantly activated in many carcinomas.
Objective:
To review the activation and role of NF-kappaB in pathogenesis and as a target for treatment and prevention in carcinoma.
Methods:
Evidence from experimental, epidemiological, preclinical studies and clinical trials cited in the literature are reviewed.
Results/Conclusion:
Cumulative evidence implicates NF-kappaB in cell survival, inflammation, angiogenesis, spread and therapeutic resistance during tumor development, progression and metastasis of carcinomas. Non-specific natural and synthetic agents that inhibit NF-kappaB have demonstrated activity and safety in prevention or therapy. NF-kappaB-activating kinases and the proteasome are under investigation for targeted prevention and therapy of carcinoma.
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