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Updated: Jul 2, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

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Published on: January 27, 2013

Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets

William J Brackenbury1, Lori L Isom

  • 1University of Michigan, School of Medicine, Department of Pharmacology, 1150 W. Medical Center Dr, 1301 MSRB III, Ann Arbor, MI 48109-0632, USA.

Expert Opinion on Therapeutic Targets
|August 13, 2008
PubMed
Abstract

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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