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Related Concept Videos

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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Related Experiment Video

Updated: Jul 2, 2026

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

Ventriculitis due to Staphylococcus lugdunensis: two case reports.

Teresa Spanu1, Donato Rigante, Gianpiero Tamburrini

  • 1Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy. tspanu@rm.unicatt.it

Journal of Medical Case Reports
|August 13, 2008
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus lugdunensis can cause severe central nervous system infections, particularly ventriculitis, in patients with external ventriculostomy drains. Prompt treatment with intrathecal vancomycin led to recovery in two pediatric cases.

Related Experiment Videos

Last Updated: Jul 2, 2026

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

Area of Science:

  • Infectious Diseases
  • Neurosurgery
  • Microbiology

Background:

  • Staphylococcus lugdunensis, a coagulase-negative staphylococcus, is recognized for its unusual virulence.
  • It is rarely associated with central nervous system infections.

Purpose of the Study:

  • To report cases of ventriculitis caused by methicillin-resistant Staphylococcus lugdunensis in pediatric patients.
  • To highlight the importance of identifying this pathogen in cerebrospinal fluid.

Main Methods:

  • Molecular identification of the causative organism.
  • Treatment with high-dose intrathecal vancomycin.
  • Clinical monitoring of patients with external ventriculostomy drains.

Main Results:

  • Two children developed ventriculitis due to methicillin-resistant Staphylococcus lugdunensis post-neurosurgery.
  • Both patients recovered without significant long-term complications.
  • Intrathecal vancomycin was effective in treating the infection.

Conclusions:

  • Accurate identification of Staphylococcus lugdunensis is critical due to its potential for severe CNS infections.
  • Patients with cerebrospinal fluid devices are at risk.
  • Clinicians must consider Staphylococcus lugdunensis in CNS infections, especially with implanted devices.