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Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
Published on: June 30, 2019
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis
Donald R Hoff1, Megan L Caraway, Elizabeth J Brooks
1Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
Abstract:
Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.
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