Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of IgG N-Glycans With Adverse Outcomes in CKD.

Kidney international reports·2026
Same author

Cilia to basement membrane signaling is a biomechanical driver in models of autosomal dominant polycystic kidney disease.

The Journal of clinical investigation·2026
Same author

Conducting a randomized controlled clinical trial on palliative care in patients with glioblastoma - what are the challenges?

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Dexmedetomidine in Palliative Medicine: From Trial Procedures to Practice Recommendations.

Journal of pain and symptom management·2026
Same author

Heterogeneity of Estimated GFR Slopes According to Etiology, Estimated GFR and Urinary Albumin-to-Creatinine Ratio in a Large Cohort of Patients With CKD.

Kidney international reports·2026
Same author

IL1β is induced in nephronophthisis but does not mediate kidney damage.

Genes & diseases·2025

Related Experiment Video

Updated: Jul 2, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

TRPP2 and TRPV4 form a polymodal sensory channel complex.

Michael Köttgen1, Björn Buchholz, Miguel A Garcia-Gonzalez

  • 1Renal Division, University Hospital Freiburg, 79106 Freiburg, Germany.

The Journal of Cell Biology
|August 13, 2008
PubMed
Summary

The primary cilium

More Related Videos

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Related Experiment Videos

Last Updated: Jul 2, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

Area of Science:

  • Cell Biology
  • Biophysics
  • Physiology

Background:

  • Primary cilia are crucial cellular sensors for mechanical stimuli.
  • The molecular basis of ciliary mechanotransduction, particularly calcium signaling, remains unclear.
  • Polycystin-2 (TRPP2) is implicated in ciliary calcium transients but is not mechanosensitive itself.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying ciliary mechanotransduction.
  • To identify the components of the ciliary mechanosensor responsible for calcium signaling.
  • To investigate the role of TRPV4 in TRPP2-mediated ciliary mechanosensing.

Main Methods:

  • Utilized renal epithelial cells with TRPV4 depletion.
  • Assessed flow-induced intracellular calcium transients.
  • Examined TRPV4-deficient zebrafish and mouse models for renal cyst development.

Main Results:

  • TRPV4 forms a mechano- and thermosensitive complex with TRPP2 within the primary cilium.
  • Depletion of TRPV4 eliminated flow-induced calcium transients in renal epithelial cells.
  • TRPV4-deficient zebrafish and mice did not develop renal cysts.

Conclusions:

  • TRPV4 is an essential component of the ciliary mechanosensor, working with TRPP2.
  • The findings challenge the established model that defective ciliary flow sensing is the primary driver of polycystic kidney disease pathogenesis.