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Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

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Temporary sutureless amniotic membrane patch for acute alkaline burns.

Ahmad Kheirkhah¹, Daniel A Johnson, Deval R Paranjpe

¹Ocular Surface Center, 7000 SW 97th Ave, Ste 213, Miami, FL 33173, USA.

Archives of Ophthalmology (Chicago, Ill. : 1960)

|August 13, 2008

Summary

A new sutureless amniotic membrane patch (ProKera) effectively treated acute alkaline burns in 5 patients. The treatment promoted rapid healing of corneal and conjunctival defects, preserving ocular surface health and preventing complications.

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Area of Science:

Ophthalmology
Regenerative Medicine
Tissue Engineering

Background:

Acute chemical burns pose a significant risk to ocular surface integrity.
Traditional treatments for severe corneal burns can be invasive and lead to complications.
The use of amniotic membrane has shown therapeutic potential in ocular surface reconstruction.

Observation:

A retrospective review assessed the clinical outcomes of 5 patients with acute alkaline burns (Grades I-III).
Patients received a sutureless temporary amniotic membrane patch (ProKera) within 8 days of injury.
The study involved eyes with extensive corneal epithelial defects and limbal/conjunctival involvement.

Findings:

ProKera insertion, performed within a mean of 3.7 days, facilitated reepithelialization of conjunctival defects in approximately 8 days and corneal defects in about 14 days.
Complete healing occurred with limbal stem cell preservation and centripetal corneal healing.
Follow-up revealed stable ocular surfaces, improved corneal clarity, and absence of symblepharon or limbal deficiency.

Implications:

Sutureless amniotic membrane application enables prompt delivery of therapeutic benefits for acute ocular burns.
This approach may preserve limbal stem cells, promoting faster healing and preventing long-term cicatricial issues.
The findings suggest ProKera is a viable, minimally invasive option for managing mild to moderate acute alkaline burns.