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Updated: Jul 2, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Transcatheter closure of postinfarction ventricular septal defect using the Amplatzer atrial septal defect occluder
Claudio Giombolini1, Salvatore Notaristefano, Stefano Santucci
1Interventional Cardiology, Silvestrini Hospital, University of Perugia, School of Medicine, Perugia, Italy. lab.emodinamica@ospedale.perugia.it
Insights
A rare ventricular septal defect after heart attack can be life-threatening. This study shows successful transcatheter closure using a specific Amplatzer device, offering a new treatment option.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Rupture of the interventricular septum is a rare but severe complication following acute myocardial infarction.
- This condition, known as post-myocardial infarction ventricular septal defect (VSD), carries high rates of morbidity and mortality.
- Traditional treatment involves surgical closure, which carries significant risks.
Observation:
- The Amplatzer occluder is a device primarily used for percutaneous closure of atrial septal defects (ASDs), patent foramen ovale (PFO), and some congenital VSDs.
- Transcatheter closure of post-infarction VSDs is infrequently described in medical literature.
- A specific case involving a large post-infarction VSD with unique anatomical features was identified.
Findings:
- Successful transcatheter closure of a large post-infarction VSD was achieved.
- The Amplatzer multifenestrated atrial septal defect occluder device was utilized for the closure.
- The device's suitability was attributed to the specific anatomical characteristics of the VSD.
Implications:
- This case demonstrates the potential for percutaneous closure of complex post-infarction VSDs using available devices.
- It suggests an alternative therapeutic option to surgical intervention for selected patients.
- Further research into transcatheter techniques for post-infarction VSDs may improve patient outcomes and reduce treatment-related risks.
Abstract:
Rupture of the interventricular septum is a rare and life-threatening complication of acute myocardial infarction. Postmyocardial infarction, ventricular septal defect is associated with very high morbidity and mortality. The therapy of this complication is the surgical closure. The Amplatzer occluder is currently used to close percutaneously atrial septal defect, patent foramen ovale, and selected congenital ventricular septal defect. Few cases are described regarding transcatheter closure of a postinfarction ventricular septal defect. Here we report a case of a large postinfarction ventricular septal defect successfully closed with Amplatzer multifenestrated atrial septal defect occluder device because of its peculiar anatomical characteristics.

