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Related Experiment Video

Updated: Jul 2, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Placental calcification in pseudoxanthoma elasticum.

Wei Ching Tan¹, Charles H Rodeck

¹Department of Obsterics and Gynaecology, Singapore General Hospital, Singapore. aileen_tan2000@yahoo.com.sg

Annals of the Academy of Medicine, Singapore

|August 13, 2008

Summary

This case report highlights placental calcification in Pseudoxanthoma elasticum (PXE). Most pregnancies in women with PXE are uncomplicated, with no increased fetal loss.

Area of Science:

Obstetrics and Gynecology
Genetics
Pathology

Background:

Pseudoxanthoma elasticum (PXE) is an inherited disorder affecting elastic tissue.
PXE is primarily caused by mutations in the ABCC6 gene.
Pregnancy complications in PXE can include cardiovascular and gastrointestinal issues.

Observation:

A 37-year-old woman with PXE presented with a markedly echogenic placenta on antenatal imaging.
Extensive placental calcification was confirmed via postpartum histology.
The patient had no antenatal complications.

Findings:

A healthy infant was delivered via Cesarean section and remained well at 6 months.
No significant maternal or fetal complications occurred during the antenatal period.

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PXE was not associated with increased fetal loss or adverse reproductive outcomes in this case.

Implications:

Pregnancy in women with PXE can be uncomplicated despite potential vascular damage.
Obstetric prognosis depends on the severity of vascular involvement.
Women with PXE can be reassured about reproductive outcomes and advised against avoiding pregnancy.