Related Experiment Video
Updated: Jul 2, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Bioethical aspects in the care of extremely preterm infants]
Mario Sebastiani1, José María Ceriani Cernadas
1Servicio de Obstetricia, Hospital Italiano de Buenos Aires. mario.sebastiani@hospitalitaliano.org.ar
Insights
Survival rates for extremely preterm infants have improved due to better prenatal and neonatal care. However, this progress has not reduced infant morbidity, raising bioethical concerns in perinatal care.
Area of Science:
- Neonatalogy
- Perinatal Medicine
- Bioethics
Context:
- Improved survival rates in extremely preterm infants over recent years.
- Advances in prenatal and neonatal care, including antenatal steroids, delivery room management, surfactant therapy, and assisted ventilation.
Purpose:
- To examine bioethical aspects of perinatal care at the threshold of viability.
- To address the rising morbidity despite improved survival rates in extremely preterm infants.
Summary:
- Enhanced neonatal care has increased survival for extremely preterm infants.
- Morbidity rates, including bronchopulmonary dysplasia, sepsis, poor growth, and neurological disorders, have not decreased and may be increasing.
- This article explores the bioethical considerations surrounding these outcomes.
Impact:
- Highlights the ethical challenges in balancing improved survival with reduced morbidity in extremely preterm infants.
- Informs discussions on optimizing perinatal care strategies and resource allocation.
- Promotes a deeper understanding of the long-term health implications for vulnerable neonates.
Abstract:
The survival rate of extremely preterm infants improved over the last years as a result of a better prenatal and neonatal care mainly due to a greater use of antenatal steroids, appropriate management in the delivery room and in the initial care, surfactant therapy, and better modalities of assisted ventilation. However, this improvement in survival has not been associated with an equal reduction in morbidity. In fact, the frequency of bronchopulmonary displasia, sepsis, poor growth, and neurological disorders in the future may have increased. The purpose of this article is to examine, from a bioethical point of view, different aspects in perinatal care at the threshold of viability.
Related Concept Videos
Ethical Issues
Ethical Concerns in Healthcare:
Nursing Ethical Principles II
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's cancer...
Nursing Ethical Principles I
Autonomy
Autonomy underscores the significance of a patient's self-determination and freedom from external control. In healthcare, respecting the...
Ethics and Bioethics
Development of the Oral Microbiota

