Related Experiment Video

Updated: Jul 2, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Subdural collections due to non-typhi Salmonella infections in two Malaysian children

H I Intan1, C D Zubaidah, A Norazah

  • 1Department of Paediatrics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Malaysia. ihakimah@yahoo.com

Singapore Medical Journal
|August 13, 2008
PubMed

Insights

Subdural collections from non-typhi Salmonella are rare in children. Prompt surgical drainage and antibiotics led to favorable outcomes in two pediatric cases, challenging previous reports on neurological sequelae.

Area of Science:

  • Pediatric Infectious Diseases
  • Neuroscience
  • Microbiology

Background:

  • Subdural collections secondary to Salmonella infection are uncommon in pediatric populations.
  • Non-typhi Salmonella serotypes are increasingly recognized as potential pathogens in invasive pediatric infections.

Observation:

  • Two pediatric cases of subdural collections caused by non-typhi Salmonella are presented: one with subdural effusion and another with empyema.
  • Clinical presentations varied, including status epilepticus and prolonged fever without localizing signs.

Findings:

  • Diagnosis was confirmed via blood and subdural pus cultures.
  • Both patients demonstrated positive responses to surgical drainage and extended systemic antibiotic treatment.
  • Contrary to prior literature, both cases achieved favorable neurological outcomes.

Implications:

  • Highlights the importance of considering non-typhi Salmonella in pediatric subdural infections.
  • Suggests that prompt intervention, including surgical management and antibiotics, can lead to favorable neurological outcomes.
  • Warrants further investigation into the pathogenesis and management of Salmonella-associated subdural collections in children.

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...