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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

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Increased effector-target cell conjugate formation due to HLA restricted specific antigen recognition

Ching Y Voss1, Sara Deola, Thomas A Fleisher

  • 1Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Immunologic Research
|August 13, 2008
PubMed
Summary

T cell receptor (TCR) interactions drive effector-target cell conjugates, indicating specific antigen recognition. This conjugate formation assay can detect and isolate functional cytotoxic T lymphocytes (CTLs).

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