Related Experiment Video
Updated: Jul 2, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
[Adult onset Still's disease]
1Medizinische Klinik III, Klinikum der Friedrich-Alexander-Universität, Krankenhausstr. 12, 91054, Erlangen, Deutschland. bernhard.manger@uk-erlangen.de
Abstract:
Adult onset Still's disease is a rare, febrile, multisystem rheumatic disease with unknown etiology, which runs an intermittent course and can either go into remission after months to years or progress to a chronic course with substantial joint destruction. The prevalence of this disease has been increasing in the last decade presumably caused by better diagnostic tools but also by a higher awareness among physicians taking care of patients with "fever of unknown origin". This review is intended to augment this trend, since research on the role of proinflammatory cytokines in this disease has led to an improved diagnostic and therapeutic repertoire over the last few years. Ferritin and interleukin-18 serum levels are valuable diagnostic parameters and blockade of interleukin-1, interleukin-6, and tumor-necrosis-factor alpha can effectively control the inflammatory activity of this disease in most cases and also in life-threatening conditions.
Related Concept Videos
Type I Diabetes III: Clinical Manifestations
Sex-linked Disorders
Huntington Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Alzheimer Disease l: Introduction
Chronic Kidney Disease II: Clinical Manifestations
