Related Experiment Video
Updated: Jul 2, 2026

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
Published on: September 21, 2021
Protein-polyamine conjugates by transglutaminase 2 as potential markers for antineoplastic screening of natural
A Lentini1, B Provenzano, C Tabolacci
1Department of Biology, University Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.
Abstract:
The role of post-translational modification of cell proteins with polyamines, a reaction catalyzed by a tissue tranglutaminase (TG, EC 2.3.2.13), in the induction of cell differentiation, represents an intriguing strategy to control cell proliferation and metastatic ability of different tumor cell lines. In this review, we focus our attention on the metabolic aspects of some natural compounds (methylxantines, retinoids and flavonoids) responsible of their antitumor effects exerted through the induction of TG activity in cancer cells.

