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Updated: Jul 2, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Hepatic veno-occlusive disease after tandem autologous stem cell transplantation conditioned by melphalan
Sana Intidhar Labidi1, Catherine Sebban2, Hervé Ghesquières2
1Department of Medical Oncology, Centre Léon Bérard, 28 Rue Laennec, 69008, Lyon, France. LABIDI@lyon.fnclcc.fr.
Abstract:
We report the case of a 58-year-old man with multiple myeloma stage III A who received tandem autologous stem cell transplantation after induction by two courses of VAD and three cycles of bortezomib-dexamethasone, due to progression under chemotherapy. The second transplantation was complicated by severe hepatic veno-occlusive disease (HVOD). The patient received defibrotide with total recovery. The occurence of HVOD after conditioning by melphalan is uncommon and the role of bortezomib was questioned.
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