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Embryonic chick corneal epithelium: a model system for exploring cell-matrix interactions.

Kathy K H Svoboda¹, Donald A Fischman, Marion K Gordon

¹Department of Biomedical Science, Texas A & M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA. ksvoboda@bcd.tamhsc.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists

|August 13, 2008

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Dr. Elizabeth Hay

Area of Science:

Developmental Biology
Cell Biology
Biochemistry

Background:

Dr. Elizabeth Hay's research career shifted from amphibian limb regeneration to extracellular matrix (ECM) roles in embryonic morphogenesis.
Her significant contributions utilized the embryonic chick corneal epithelium as a key model system.

Purpose of the Study:

To review key discoveries on the role of the extracellular matrix (ECM) in embryonic development, focusing on Dr. Hay's work.
To highlight the utility of the embryonic chick corneal epithelium model in understanding cell-matrix interactions.

Main Methods:

Utilized the embryonic chick corneal epithelium model.
Investigated cell production of fibrillar collagen.
Examined epithelial cell responses to collagenous substrates and purified ECM molecules.

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Analyzed actin cytoskeleton reorganization in response to ECM.

Studied signal transduction pathways involved in ECM-induced cellular changes.

Main Results:

Demonstrated that embryonic corneal epithelial cells produce fibrillar collagen.
Showed corneal epithelial cells increase ECM production when cultured on collagenous substrates.
Revealed that purified ECM molecules induce actin cytoskeleton reorganization in epithelial sheets.
Established foundational theories of cell-matrix interactions.

Conclusions:

The embryonic chick corneal epithelium is a powerful model for studying ECM's influence on cytoskeleton, cell migration, growth, and differentiation.
Dr. Hay's work provided critical insights into cell-matrix interactions during embryonic development.
Recent studies continue to elucidate ECM-mediated signaling pathways using this model.