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Updated: Jul 2, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Dengue fever during pregnancy. Cases report]
Rocio Rosado León1, Mario R Muñoz Rodríguez, Elizabeth Soler Huerta
1Delegación Veracruz Norte, IMSS, Mexico. rocio.rosado@imss.gob.mx
Ginecologia Y Obstetricia De Mexico
|August 14, 2008
Summary
Dengue infection during pregnancy can lead to severe maternal complications like premature labor and bleeding. However, dengue virus was not detected in newborns from infected mothers.
Area of Science:
- Infectious Diseases
- Maternal-Fetal Medicine
- Virology
Background:
- Dengue fever is endemic in tropical and subtropical areas, historically affecting children but increasingly seen in adults.
- Recent increases in adult dengue cases include pregnant women, necessitating further investigation into maternal and neonatal outcomes.
Purpose of the Study:
- To analyze dengue virus infection in pregnant women and assess associated maternal and neonatal complications.
- To determine the presence of dengue-specific antibodies (IgG and IgM) in neonates born to infected mothers.
Main Methods:
- Case series analysis of eight pregnant women diagnosed with dengue virus infection using ELISA IgM and IgG tests.
- Clinical data, pregnancy outcomes, and neonatal status were reviewed for all participants.
Main Results:
- Eight dengue cases during pregnancy included three dengue fever and five dengue hemorrhagic fever.
- Maternal complications comprised threat of abortion, premature labor, postsurgical bleeding, oligohydramnios, and pleural effusion.
- Two neonates presented with fever and were classified as septic; however, no dengue-specific IgG or IgM antibodies were detected in any neonates.
Conclusions:
- Dengue infection during pregnancy poses significant risks for severe maternal complications.
- Neonates born to mothers with dengue infection did not show evidence of vertical transmission of the virus based on serological markers.
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