Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The primate gut microbiota contributes to interspecific differences in host metabolism.

Microbial genomics·2024
Same author

Biological Effective Radiation Dose for Multiple Myeloma Palliation.

Advances in radiation oncology·2023
Same author

Can't buy me meaning? Lay theories impede people from deriving meaning and well-being from consumption.

Current opinion in psychology·2022
Same author

Short-Term Relocation Stress-Induced Hematological and Immunological Changes in <i>Saimiri boliviensis boliviensis</i>.

Journal of immunology research·2021
Same author

Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys.

Brain : a journal of neurology·2021
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Targeted radionuclide therapy.

Lawrence E Williams1, Gerald L DeNardo, Ruby F Meredith

  • 1Radiology Division, City of Hope National Medical Center, Duarte, California 91010, USA. lwilliams@coh.org

Medical Physics
|August 14, 2008
PubMed
Summary
This summary is machine-generated.

Targeted radionuclide therapy (TRT) uses targeted agents to treat cancer. Enhancing TRT for solid tumors requires higher doses, improved targeting, and patient-specific imaging for better treatment outcomes.

More Related Videos

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiopharmaceutical therapy

Background:

  • Targeted radionuclide therapy (TRT) utilizes radiolabeled agents to target cancer cells.
  • Current TRT applications are primarily in B-cell lymphoma.
  • Expanding TRT to solid tumors necessitates increasing the absorbed radiation dose.

Purpose of the Study:

  • To review current strategies and future directions in targeted radionuclide therapy.
  • To identify methods for enhancing TRT efficacy in solid tumors.
  • To address limitations in absorbed dose estimation for improved treatment correlation.

Main Methods:

  • Review of radionuclide carriers (antibodies, liposomes, nanoparticles) and their uptake in tumor tissue.
  • Discussion of methods to increase absorbed dose: multistep targeting, chemotherapy, external sequestration.
  • Exploration of toxicity management, including marrow replacement.
  • Emphasis on patient-specific dosimetry using hybrid SPECT/CT and PET/CT imaging.

Main Results:

  • TRT agents have been developed using various radionuclide emitters and carriers.
  • Uptake in malignant tissue is a key metric for targeting specificity.
  • Significant dose escalation is needed for solid tumor TRT.
  • Patient-specific imaging is crucial for accurate absorbed dose estimation and toxicity correlation.

Conclusions:

  • Advancements in TRT require strategies to increase tumor absorbed dose and overcome targeting challenges.
  • Minimizing toxicity, particularly to red marrow, is essential for treatment enhancement.
  • Integrating patient-specific imaging data will improve the correlation between toxicity, dosimetry, and treatment efficacy in TRT.