Related Experiment Video
Updated: Jul 2, 2026

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
Published on: December 23, 2022
Mode coupling in living systems: implications for biology and medicine
1Department of Physics, Northeastern University, 110 Forsyth Street, Boston, MA 02115, USA. john.swain@cern.ch
Abstract:
Complex systems, and in particular biological ones, are characterized by large numbers of oscillations of widely differing frequencies. Various prejudices tend to lead to the assumption that such oscillators should generically be very weakly interacting. This paper reviews the basic ideas of linearity and nonlinearity as seen by a physicist, but with a view to biological systems. In particular, it is argued that large couplings between different oscillators of disparate frequencies are common, being present even in rather simple systems which are well-known in physics, although this issue is often glossed over. This suggests new experiments and investigations, as well as new approaches to therapies and human-environment interactions which, without the concepts described here, may otherwise seem unlikely to be interesting. The style of the paper is conversational with a minimum of mathematics, and no attempt at a complete list of references.
Related Concept Videos
¹H NMR: Long-Range Coupling
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.
Ligand Binding and Linkage
Ligand Binding and Linkage
NMR Spectroscopy: Spin–Spin Coupling
Non-equilibrium in the Cell
Coupled Reactions
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions. Cells...
