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Related Experiment Videos

Cardiovascular changes in response to uterine stimulation.

A Robbins1, Y Sato

  • 1Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.

Journal of the Autonomic Nervous System
|April 1, 1991
PubMed
Summary

Uterine horn distension triggers cardiovascular changes in estrous rats, mediated by the hypogastric nerve. This reflex, involving decreased heart rate and blood pressure, is linked to sympathetic efferent nerve activity.

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Area of Science:

  • Physiology
  • Neuroscience

Background:

  • Cardiovascular responses to internal organ distension are complex.
  • The role of specific neural pathways in mediating uterine-cardiovascular reflexes is not fully understood.

Purpose of the Study:

  • To investigate the cardiovascular responses to uterine horn distension in rats.
  • To identify the afferent and efferent neural pathways involved in this reflex.

Main Methods:

  • Anesthetized rats (estrous and diestrous phases) underwent uterine horn distension.
  • Nerve transections (pelvic, hypogastric, vagus) were performed to assess afferent and efferent pathways.
  • Cardiovascular parameters (blood pressure, heart rate) and neural activity (single unit, multi-unit) were recorded.

Main Results:

Related Experiment Videos

  • Uterine horn distension caused significant decreases in heart rate and blood pressure in estrous rats, but not diestrous rats.
  • Hypogastric nerve transection abolished or attenuated these cardiovascular responses.
  • Sympathetic efferent activity in the renal nerve decreased in parallel with the cardiovascular changes.

Conclusions:

  • The hypogastric nerve is crucial for transmitting signals from the uterus to the cardiovascular system.
  • The observed cardiovascular changes are mediated by a reflex involving the hypogastric nerve and sympathetic efferent pathways.
  • Parasympathetic pathways via the vagus nerve do not appear to be involved in this inhibitory reflex.