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Measuring Psoriasis Severity at Home
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Cardiovascular morbidity in psoriatic arthritis

D D Gladman1, M Ang, L Su

  • 1Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada. dafna.gladman@utoronto.ca

Annals of the Rheumatic Diseases
|August 14, 2008
PubMed

Insights

Patients with psoriatic arthritis (PsA) face higher risks of cardiovascular disease (CVD), including heart attack and hypertension. Severe psoriasis is a key predictor, alongside traditional risk factors like diabetes.

Area of Science:

  • Rheumatology
  • Cardiology
  • Dermatology

Background:

  • Psoriasis and psoriatic arthritis (PsA) are linked to increased cardiovascular mortality.
  • Patients with PsA often exhibit a higher prevalence of cardiovascular disease (CVD) risk factors.

Purpose of the Study:

  • To characterize cardiovascular morbidity in PsA patients.
  • To determine the prevalence of CVD in this population.
  • To identify risk factors contributing to CVD development in PsA.

Main Methods:

  • Prospective follow-up of PsA patients at the University of Toronto.
  • Standardized data collection on disease features and comorbidities.
  • Identification of CVD events (MI, angina, hypertension, CVA) and comparison with general population data using standardized prevalence ratios (SPRs).
  • Cox relative risk regression analysis for risk factor identification.

Main Results:

  • 155 out of 648 PsA patients developed at least one major cardiovascular event.
  • Statistically significant increased SPRs were observed for myocardial infarction (MI), angina, and hypertension.
  • Diabetes, hyperlipidaemia, and high Psoriasis Area and Severity Index (PASI) scores were associated with increased CVD risk.

Conclusions:

  • PsA patients exhibit a significantly elevated risk of cardiovascular morbidities compared to the general population.
  • Severe psoriasis, indicated by high PASI scores, is a notable predictor of CVD in PsA patients.
  • Management of PsA should consider cardiovascular risk assessment and mitigation strategies.
Abstract

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