Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Bone Formation by Endochondral Ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease.

Diabetologia·2025

Same author

Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.

Pain reports·2025

Same author

Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort.

Pain reports·2025

Same author

Effects of Exergaming on Physical Fitness of Youth with Overweight and Obesity: A Systematic Review with Meta-Analysis.

Games for health journal·2025

Same author

Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2024

Same author

Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study.

FEBS letters·2024

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

Angiogenesis in osteoarthritis.

Sadaf Ashraf¹, David Andrew Walsh

¹Academic Rheumatology, University of Nottingham, Nottingham, UK.

Current Opinion in Rheumatology

|August 14, 2008

Summary

Angiogenesis, or blood vessel growth, is closely linked to osteoarthritis pain and progression. Inhibiting this process shows promise as a new therapeutic strategy for osteoarthritis.

Area of Science:

Orthopedics
Vascular Biology
Rheumatology

Background:

Osteoarthritis (OA) is increasingly understood to involve complex interactions beyond cartilage degradation.
Angiogenesis, the formation of new blood vessels, plays a significant role in OA pathogenesis.
Understanding these vascular mechanisms is key to developing novel OA therapeutics.

Purpose of the Study:

To review recent findings on the role of angiogenesis in osteoarthritis.
To contextualize this evidence within existing literature.
To explain the contribution of angiogenesis to OA pain and disease progression.

Main Methods:

Literature review of recent studies on angiogenesis in OA.
Analysis of molecular mechanisms and consequences of vascularization in OA.

More Related Videos

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Related Experiment Videos

Last Updated: Jul 2, 2026

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Discussion of advanced imaging techniques for visualizing joint vascularity.

Main Results:

Inflammation and angiogenesis are interconnected in OA, affecting chondrocytes, tissue growth, and bone development.
Vascularization is associated with innervation, contributing to OA-related pain.
Advanced imaging (MRI, ultrasound) reveals abnormal vascularity not seen with conventional radiography, challenging the cartilage-centric view of OA.

Conclusions:

The molecular basis and effects of angiogenesis in OA are being clarified.
Inhibiting angiogenesis presents a promising therapeutic avenue for OA treatment in humans and animal models.
Improved visualization techniques will enhance OA understanding and therapeutic trial efficacy.