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Updated: Jul 2, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Optical coherence tomography findings for nanophthalmic eyes
Ward R Bijlsma1, Mary J van Schooneveld, Allegonda Van der Lelij
1Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands. w.r.bijlsma@umcutrecht.nl
Purpose:
To describe the optical coherence tomography (OCT) findings for nanophthalmic eyes.
Methods:
: In this retrospective, single-center, observational case series, 15 patients (28 eyes) with axial lengths of
Results:
The foveae of nanophthalmic eyes had diminished foveal depression due to thickened outer retinal layers. One patient with papillomacular folds was identified as having posterior microphthalmos. There was a good correlation between axial length on one hand and foveal thickness, foveal center point thickness, macula volume, and RFD on the other hand (r = -0.58, -0.61, -0.56, and -0.70 with P = 0.003, 0.001, 0.004, and 0.000, respectively). The average RFD for eyes with normal axial lengths was 0.43.
Conclusions:
OCT findings for nanophthalmic eyes with foveal underdevelopment are different from posterior microphthalmos and foveal hypoplasia seen in other disorders. The new measure RFD is a useful tool in ocular tomography.
