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Synthesis and in vitro evaluation of imidazole-based wakayin analogues

Hung Hoang1, Xiaofen Huang, Edward B Skibo

  • 1Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA.

Organic & Biomolecular Chemistry
|August 14, 2008
PubMed

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Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).