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Updated: Jul 2, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Paediatric renal tumours: recent developments, new entities and pathological features.
Neil J Sebire1, Gordan M Vujanic
1Department of Histopathology, Great Ormond Street Hospital/Institute of Child Health, London, UK.
Histopathology
|August 14, 2008
Summary
Diagnosing paediatric renal tumours relies on histopathology. Advances in molecular biology and immunohistochemistry improve the diagnosis of various childhood kidney cancers, including Wilms' tumour.
Area of Science:
- Pediatric Pathology
- Oncology
- Nephrology
Background:
- Paediatric renal tumours are common childhood solid neoplasms.
- Accurate diagnosis and treatment depend heavily on histopathological findings.
- Includes Wilms' tumour, mesoblastic nephroma, clear cell sarcoma, rhabdoid tumour, and paediatric renal cell carcinoma variants.
Purpose of the Study:
- To review key diagnostic features of paediatric renal tumours.
- To highlight recent advances in classification and diagnostic criteria.
- To emphasize the role of molecular biology and immunohistochemistry.
Main Methods:
- Review of current literature and diagnostic guidelines.
- Analysis of histopathological features.
- Integration of molecular and immunohistochemical findings.
Main Results:
- Established entities like Wilms' tumour alongside distinct neoplasms.
- Molecular and immunohistochemical techniques enable reliable diagnosis from small biopsies.
- Recent updates in classification and diagnostic criteria have been identified.
Conclusions:
- Histopathology is crucial for diagnosing paediatric renal tumours.
- Modern techniques enhance diagnostic accuracy, even with limited samples.
- Staying updated on new classifications and criteria is essential for pathologists.
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